重癥患者機體受到感染之后，炎性反應呈級聯式放大，而人體為對抗炎癥反應而形成的代償性反應綜合征，一旦患者發生全身性炎性反應與代償性抗炎反應紊亂，可以導致其體內的環境穩態被破壞，出現組織損傷，最終出現多種器官的功能衰竭[1]。健帆公司針對不同類型危重癥患者提供吸附解決方案，健帆HA一次性血液灌流器，原研經典，廣譜吸附，有效清除以炎癥介質為代表的中大分子，可用于膿毒癥[2-3]、重癥急性胰腺炎（SAP）[4-5]、急性呼吸窘迫綜合征（ARDS）[6-7]等炎癥因子相關性疾病及心外科手術患者[8]；CA330細胞因子吸附柱，中國首個獲批醫療器械注冊證的細胞因子吸附類產品，專用于膿毒癥患者炎癥早期或細胞因子風暴期。血液吸附危重癥領域治療模式多樣，臨床上可以根據實際情況單獨灌流使用，也可與其他血液凈化模式聯合使用，如HP+HD/HDF/CVVH、PFAD/CPFA[17]、(PFAD-HD)/ CPFA-CRRT[17]、HP+CPB、HP+ECMO，進行全血或者血漿灌流治療。
參考文獻：
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[2]Zhao Huang, Si-rong Wang, Zi-li Yang, and Ji-yun Liu. Effect on Extrapulmonary Sepsis-Induced Acute Lung Injury by Hemoperfusion With Neutral Microporous Resin Column[J]. Therapeutic Apheresis and Dialysis, 2012:1-8.
[3]Huang Z, Wang SR, Su W, Liu JY. Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column. Ther Apher Dial.2010 Dec;14(6):596-602.
[4]Sun, Shiren, et al. "High-volume hemofiltration plus hemoperfusion for hyperlipidemic severe acute pancreatitis: a controlled pilot study." Annals of Saudi medicine 35.5 (2015): 352-358.
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[6]Xu, Xuefeng, et al. "Effect of HA330resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model." Annals of intensive care 7.1 (2017): 84.
[7]Li, Cong, Nana Xu, and Tie Xu. "Therapeutic Effects of Hemoperfusion Combined with High Volume Hemofiltration on Acute Respiratory Distress Syndrome Short Title: Treatment of ARDS." Revista Argentina de Clinica Psicológica 29.3(2020):311.
[8]Zijian He, etal. The Efficacy of Resin Hemoperfusion Cartridge on Inflammatory Responses during Adult Cardiopulmonary Bypass. Blood Purif.2021 Jun 9;1-7.
[9]ZHANG Lin,et al.Clinical study of mechanical ventilation combined with hemoperfusion and purification in the treatment of pneumothorax complicated by respiratory failure caused by traffic accident.Chin J Emerg Resusc Disaster Med.2021.
[10]Yuan,Hai,et al."Efficacy of two combinations of blood purification techniques for the treatment of multiple organ failure induced by wasp stings."Blood Purification 42.1 (2016):49-55.
[11]Zijian He,et al.The Efficacy of Resin Hemoperfusion Cartridge on Inflammatory Responses during Adult Cardiopulmonary Bypass.Blood Purif.2021 Jun 9;1-7.
[12]Xu,Xuefeng,et al."Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model."Annals of intensive care 7.1 (2017):84.
[13]Li,Cong,Nana Xu,and Tie Xu."Therapeutic Effects of Hemoperfusion Combined with High Volume Hemofiltration on Acute Respiratory Distress Syndrome Short Title:Treatment ofARDS."Revista Argentina de Clinica Psicológica 29.3 (2020):311.
[14]Wang,Y.T.,et al."Effects of hemodialysis and hemoperfusion on inflammatory factors and nuclear transcription factors in peripheral blood cell of multiple organ dysfunction syndrome."Eur Rev Med Pharmacol Sci 20.4 (2016):745-50.
[15]Huang Bin,et al.Clinical study of continuous veno-venous hemofiltration combined with hemoperfusion in the treatment of severe burn sepsis.Journal of Clinicalemergency(China).2019:1009-5918.
[16]Prof.Claudio Ronco.CENTRO SPECIALIZZATO REGIONALE.PER LE TERAPIE DIALITICHE NELL'INSUFFICIENZA RENALE ACUTA E CRONICA E PER LE TECNOLOGIE EXTRACORPOREE di SUPPORTO MULTI-ORGANICO.2020.
[17]Ronco, C., & Bellomo, R. (2022). Hemoperfusion: technical aspects and state of the art. Critical care (London, England), 26(1), 135. https://doi.org/10.1186/s13054-022-04009-w.
臨床應用
急性中毒吸附解決方案
血液灌流可用于人體內內源性和外源性代謝產物、毒物及余量藥物的清除,已被寫入多項急性中毒專家共識，針對各類急性中毒患者，HA一次性血液灌流器，原研經典，足程凈化，可用于有機農藥中毒[1-5]、藥物中毒[6-7]、除草劑中毒[9-13]、毒蕈中毒[14-16]、蜂蟄傷[17]等急性中毒的搶救治療。臨床上可以利用多類血液凈化動力裝置單獨灌流使用，也可與其他血液凈化器聯合使用，進行全血或者血漿灌流治療?？稍诠嗔鳈C(JF-800A),Future F20血液凈化設備、透析機、CRRT機（如健帆DX-10）等多種血液凈化設備上完成治療。
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[3]杜宇,牟奕,趙立強.血液灌流治療次數對重度急性有機磷農藥中毒療效和預后的影響[J].中國中西醫結合急救雜志,2013,20(5):289-292.
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[6]吳剛,陳陣劉易玨早期床旁血液灌流治療急性抗精神病藥物中毒的臨床觀察[J].現代醫藥衛生,2015,31(7):1042-1044.
[7]郭利濤,劉昱,張蕾,王雪,等.血液灌流救治百草枯中毒方法探討[J].重慶醫學,2013,42(5):552-553.
[8]Chen AB, Li F, Di EM, Zhang X, Zhao QY, Wen J. Influence of strengthened hemoperfusion combined with continuous venovenous hemofiltration on prognosis of patients with acute paraquat poisoning: SHP + CVVH improve prognosis of acute PQ patients. BMC Pharmacol Toxicol. 2020 Jul 6;21(1):49.
[9]孫亮,燕彭波,李國峰,等.雙罐串聯血漿灌流對血漿百草枯清除效果的研究[J].中國血液凈化,2013,12(3):149-151.
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[17]程輝,文申英,劉超.血液灌流聯合連續性腎臟替代治療在蜂蜇傷致橫紋肌溶解合并急性腎損傷中的應用價值[J].臨床和實驗醫學雜志,2020,19(16):4.
